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Vitamin B12 is needed to maintain good metabolism, health of blood cells and nerves

Serum and red blood cell folate levels confirm folate deficiency

Absorption, plasma transport, and cellular retention of cobalamin analogues in the rabbit: evidence for the existence of multiple mechanisms that prevent the absorption and tissue dissemination of naturally occurring cobalamin analogues

However, the difference in improvement between the moderately improved and No Change groups was not statistically significant

Generally, up to 1000 mcg a day of an oral tablet to treat a deficiency is considered safe

Thiamin supplements may also help for people who experience: malabsorption syndrome severe, prolonged vomiting gastric bypass surgery renal replacement therapy hyperthyroidism People who are pregnant, lactating, or use diuretics may also benefit from vitamin B1 supplements