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glutathione deficiency paracetamol Divergent effects of depletion on isocitrate dehydrogenase 1 and the pentose phosphate pathway in hamster liver Jin 2020 Physiological Reports Full article: Paracetamol ( acetaminophen) overdose Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S transferase Pi PNAS The Truth About Paracetamol and Glutathione Levels Solved The following figure shows the metabolism of the Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione depletion biomarkers ophthalmic acid and 5 oxoproline in humans and rats Integrative Biology (RSC Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect
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