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[4] Red flag symptoms requiring immediate medical assessment include: progressive or worsening neurological symptoms, changes in vision, significant gait disturbance, or cognitive decline

Vitamin B12 and Cobalt Allergy Cobalt is the central atom contained within a vitamin B12 molecule, which is why a cobalt allergy can trigger acne in the course of vitamin B12 therapy (6)

Oral supplements, on the other hand, require ingestion and absorption through the digestive system

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This was exemplifi ed by the fact that urinary excretion of methylcobalamin was one-third less that of cyanocobalamin.[1] Another point of interest regarding B12 supplementation is the commonly held belief that intramuscular injections of B12 are more effective than oral supplementation