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Although little is known, it was demonstrated that zinc(II) deficiency increased the level of NO and superoxide anion by the inhibition of the N -methyl-d-aspartate receptor (NMDAR) [45] As described on PC12 cells, NMDAR activation leads to an increase in cytoplasmic calcium levels and, thus, to increased ROS [66]

They are sometimes discussed together because both have been studied in tissue-repair research models, but the published literature treats them as separate research subjects

May 20 2020;12(5)doi:10.3390/nu12051488 Valls RM, Pedret A, Calderon-Perez L, et al

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This is mostly because the majority of the systematic reviews and randomised clinical trials measure changes in body fat percentage or body composition, rather than more specific, regional fat loss

FIGURE 9 Discussion Unfavorable environmental stimulation can alter cellular redox homeostasis, which causes the excessive generation of ROS