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The FDA label also explicitly states it is not indicated for weight loss management and notes that long-term cardiovascular safety has not been established

Data summary Medical History with Nutritional Aspect Biochemistry with Nutritional Aspect Medications That May Adversely Affect Nutritional Status Summary of medications, nutrients and transporters Biochemistry Recent relevant biochemistry indicates - - high-normal B12 levels - evidence indicates elevated B12 levels diminish cognitive function therefore advisable to check B12 levels prior to next scheduled injection, and if still within high-normal range then consider reducing frequency of interventions from 3-monthly to 6-monthly

Most people find them tolerable and not painful and also find that the benefit outweighs the discomfort that can come with any injection

The AEs were similar between doses

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Compare that to the 5 minutes of manual calculation, and the risk of a misplaced decimal, and the calculator earns its place in every researcher toolkit