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Moreover, hyperglycemia impairs the expression of Sox9, a key factor of Paneth cell differentiation involved in stem cell maintenance and the expression of stem cell markers Lgr5 and Musashi RNA-binding protein 1 (Msi1) and transit-amplifying cells marker prominin 1 (Prom1)

If muscle perfusion is poor as a result of systemic hypotension or local vasoconstriction then an intramuscular injection will not be absorbed until muscle perfusion is restored