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Accordingly, production of the endogenous antioxidant glutathione (GSH) by glial cells within the brain [8], particularly astrocytes [8,9,10], is a critical function, as most antioxidants are unable to cross the blood brain barrier

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Cellular stress responses: cell survival and cell death

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At the forefront of these resistance mechanisms is the phenomenon of lysosomal drug sequestration, which represents a fundamental obstacle to effective chemotherapy across diverse cancer types

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