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The substrate binding modes were compared among taurine to hTauT, GABA to hGAT1 (PDB: 7Y7W, GABA transporter subfamily) 35 , glycine to hGlyT1 (PDB: 8WFI, neurotransmitter amino acid transporter subfamily) 38 , and noradrenaline to hNET (PDB: 8ZPB, MAT subfamily) 39 in their occluded conformations (Supplementary Fig

5-Amino-1MQ Mechanism and Integration into the Stack 5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide (a form of vitamin B3) and reduces NAD+ availability in cells