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The metabolite of MPTP, MPP + , induces mitochondrial dysfunction, increases oxidative stress, and leads to neuronal death, exhibiting PD-like pathological characteristics 21

Thrasyvoulides A, Lymberi P

So, we also assessed changes in fractional Fe 2+ induced by lethal glutathione depletion by DEM

The slight difference between the Adjusted R 2 and Predicted R 2 values suggests that the model is reliable and can be confidently used for designing future experiments

Through these coordinated effects, they attenuate S aggregation, promote proteostatic clearance, preserve dopaminergic neuron integrity, and maintain blood brain barrier stability