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Earlier work by the same group demonstrated the platforms versatility, employing FRET peptide probes and ELISA to analyze MMP14 proteolytic activity and expression on EVs, highlighting its dual utility in both functionalization and biomarker analysis [192]

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Taken together, it is tempting to speculate that by affecting MDM2, Set7/9 also attenuates the expression of ROS-inducible RelA/MDM2 target genes

Moreover, as mentioned above, p53 is a key regulator of both autophagy and apoptosis pathways 61 and its function is highly regulated by PTMs 62

Our results so far indicated that restoring the Nnt WT/WT genotype in islets with a BL/6J background suffice to restore the glucose and FCCP regulation of mitochondrial glutathione oxidation and NAD(P)H levels to a similar extent as that previously observed in BL/6N mice