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As mentioned earlier, Glutamate lies in the intersection of multiple metabolic pathways and participates in the amino acid metabolic cycle through transamination reactions (e.g., glutamine transaminase/glutamine transaminase, ALT/AST) to produce -ketoglutarate (a TCA cycle intermediate), which connects carbon and nitrogen metabolism

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In IL-10-deficient murine models, everolimus ameliorates CD-like ileitis [109], highlighting its potential anti-inflammatory mechanisms