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93,94,95,96 Advancements in carrier technology and nucleic acid modification techniques have led to significant progress in overcoming these challenges, as exemplified by the first siRNA drug, patisiran (Onpattro), which has been approved for treating hereditary transthyretin-mediated amyloidosis by degrading mRNA encoding transthyretin (TTR)

doi: 10.1038/s41467-022-31218-2

They reported a decreased melanin index measured at six body sites (but statistically significant only at two sites, namely the right side of the face ( p =0.021) and the sun-exposed left forearm ( p =0.036))

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Implications for combined spinal-epidural anesthesia