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Chromatin insulators derived from the chicken hypersensitive site-4 (cHS4) of the -globin locus [166] were thus introduced into -globin LVs, to increase efficacy and safety [148], [167]

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doi: 10.1098/rstb.2015.0425 19 Vakifahmetoglu-NorbergHOuchidaATNorbergE

Modified NAD and glutathione metabolism is associated with a number of diseases, but no data exist of how specific pathology is shifting blood redox profile

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