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Anything that is severe, worsening, or systemic is a reason to stop and seek a clinician rather than to adjust the protocol

The inability to access the most phenotypically relevant cell types affected by FRDA, being sensory neurons, cardiomyocytes and pancreatic cells, is a major barrier to unravelling the complex molecular mechanisms underpinning disease progression

MR angiography of peripheral, carotid, and coronary arteries