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PMC+1 Many studies also note that longer trials, larger sample sizes, and standardization are still needed to fully validate glutathiones efficacy

Additionally, NRH, the reduced form of nicotinamide ribose (NR), ameliorated aminoglycoside-induced hearing loss and attenuated HC damage by increasing NAD + levels and activating SIRT1 in the cochlea [117]

Significantly, these biological processes become dysfunctional with age and are relevant in the pathogenesis of age-related syndrome [88,89] (Figure 2)

1e,f and Supplementary Table Tab 1)

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