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The diagnosis of PCOS poses inherent challenges due to its diverse clinical manifestations and the overlap of its symptoms with other prevalent endocrine disorders

The rate constants from our deglutathionylation assays between 6.4 10 4 and 1.4 10 6 M 1 s 1 are very similar to the rate constants for PfGrx or plant and mammalian glutaredoxins from discontinuous or coupled enzymatic assays with other high and low molecular weight GSSR substrates (Table 1) 9,11,14,19 , thus confirming our assay as an alternative reliable method for the direct analysis of enzyme-catalyzed deglutathionylations

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Naliboff BD, Stephens AJ, Lai HH et al: Clinical and psychosocial predictors of urological chronic pelvic pain symptom change in 1 year: A prospective study from the mapp research network