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Wu GQ, Jia BY, Li JJ, Fu XW, Zhou GB, Hou YP, Zhu SE

gain-of-function mutations in voltage-gated sodium channel genes increase neuronal excitability and are associated with PDPN

alternatively, tyramine is converted to octopamine via hydroxylation catalyzed by dopamine beta-hydroxylase (DBH)/ dopamine beta-monooxygenase (EC 1.14.17.1)