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Blood tests can determine B12 status, and if deficiency is confirmed, appropriate supplementation or treatment (such as intramuscular injections for pernicious anaemia) can be initiated according to NHS protocols

Notably, the activation of iron-regulated inflammasomes ultimately leads to oxidative stress and ferroptosis in RPECs (241)

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Furthermore, these will also contribute to the understanding of neurodegenerative disease pathogenesis, progression, monitoring and treatment

Regulation of GCL modifier subunit (GCLM) As stated above, the light subunit of GCL plays a critical regulatory role on the overall function of the enzyme (Huang et al., 1993a