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Therefore, when modulating the gut microbiota to alter SCFA levels, it is crucial to simultaneously consider their bioavailability at both the local intestinal and systemic levels to avoid the metabolic burden caused by excess energy

10.1016/j.redox.2024.103445 49 PanzaE.BelloI.SmimmoM.BrancaleoneV.MitidieriE.BucciM.et al (2022)

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There is evidence that acrolein can activate the protein kinase C (PKC), which is responsible for the phosphorylation of the cytosolic subunits of the NADPH oxidase, promoting the assembly of the activated membrane complex [33, 55, 56, 86]

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