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With the development of ADC approach, PBD has been used as a payload associated with specific antibodies in the treatment of different diseases, limiting the high toxicity associated with this molecule

Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption

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doi: 10.3390/nu11050946 63 McCubreyJ

Growth Factor Signaling and Synaptic Plasticity Mechanisms The most striking finding in Dihexa research is its potency