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Its strongest activity is directed toward the melanocortin-1 receptor (MC1R), which regulates melanin production within melanocytes

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GHK-Cu also exerts anti-inflammatory effects by inhibiting the release of pro-inflammatory cytokines (IL-6, TNF-alpha) and by modulating the activity of the nuclear factor NF-kB

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doi:10.1146/annurev.nutr.24.012003.132440

A 2021 research published in Environmental Sciences Europe has found that toxin exposure may contribute to chemical intolerance, mast cell activation, and histamine intolerance (26)