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Using any enemas regularly for a long time can cause the bowel muscle to weaken, which is linked to constipation and inflammation of the bowel

[5] Historical series in chronic-kidney-disease populations further underscore risk: moderate renal impairment alone predisposed recipients to potassium surges despite apparently normal baseline laboratory values

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During diabetes, retinal microglia assume a reactive phenotype, which results in the propagation of pro-inflammatory signalling and inflammatory damage (38)

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