According to NICE Clinical Knowledge Summaries and the British National Formulary (BNF), the recommended treatment regimens are: For patients without neurological involvement : Initial treatment: hydroxocobalamin 1 mg intramuscularly three times a week for 2 weeks Maintenance: hydroxocobalamin 1 mg intramuscularly every 3 months for life For patients with neurological involvement : Initial treatment: hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement Maintenance: hydroxocobalamin 1 mg intramuscularly every 2 months for life If neurological symptoms are present, treatment should be started urgently to prevent irreversible damage
This effect was partially explained by the associated activity of STAT3 (Signal Transducer and Activator of Transcription 3), RXR (Retinoid X Receptor), and Nrf2 (Nuclear factor erythroid 2-related factor 2), which are essential transcriptional factors for survival, repair, proliferation, and cellular protection against oxidative stress [51]
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Biasi F, Tessitore L, Zanetti D, Cutrin JC, Zingaro B, Chiarpotto E et al
Regulation of human immune and inflammatory responses by dietary fatty acids
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