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The finding that TICs, rather than differentiated tumor cells, grow in 3D gels offers a unique opportunity to unveil TIC-specific signaling pathways and therapeutic targets common to various cancer types

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The holistic effect of all extrinsic factors accounting for the phase transformation is to shield or neutralize the charges at the N or C terminal ends, as this has been also confirmed by specific site directed mutations of key residues of the protein (Pancoe et al., 2022)

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