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57 This triggers the transcription of genes encoding antioxidants such as SOD, catalase, GSH, glutathione reductase (GR), GSH S-transferase (GSTP), GPX, TRXR, NADPH quinone oxidoreductase 1 (NQO1), and heme oxygenase-1 (HO-1), which neutralize ROS and protect cells against oxidative stress, especially in conditions such as cancer, where ROS levels are elevated 57 (Fig

Improved regulation of CBF in response to both transient hyper- and hypotension subsequently protects cerebral microvasculature from hyperperfusive injury and damage as well as ensuring cerebral perfusion is able to match metabolic demand during periods of reduced driving pressures (i.e., orthostatic stress) (Korad et al., 2024

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doi: 10.1210/en.2008-1088 43

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Radiosensitization of multiple brain metastases using AGuIX gadolinium based nanoparticles (NANO-RAD)