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Indirect evidence for autonomic dysfunction

Abstract To develop an LCMS/MS method for simultaneous quantification of mildronate and L-carnitine, and to investigate the pharmacokinetic profile of mildronate in rats, its effect on L-carnitine homeostasis, as well as the exposure characteristics, underlying mechanisms, and their associations with therapeutic efficacy and toxicity risks

The clinical and biochemical outcomes for both groups, before and after the 12-week intervention, are demonstrated in Table 2

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