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Acute liver failure (ALF) Acute liver failure (ALF) is a severe, rapidly progressive condition that leads to hepatic encephalopathy and synthetic dysfunction within 26 weeks or less, and is accompanied by an INR (International Normalized Ratio) of 1.5 in patients without cirrhosis and without previous liver diseases [124]

In addition, developmental pathways such as Wnt/-catenin have become new therapeutic targets

Int J Biol Chem

Autism 6 , 1 (2015)

Regul Toxicol Pharmacol

Evidence also indicated a direct association between phases of migraine attacks and calcitonin gene-related peptide (CGRP), mitochondrial disorders, monoaminergic pathway, magnesium deficiency, and higher serum levels of glutamate (13, 14)