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Data availibility All data generated or analyzed during this study are included in this published article

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CBD was able to prevent the increase of microRNAs associated with depression in the ventromedial prefrontal cortex in an unpredictable chronic stress induction model, with antidepressant-like effects mediated by the 5HT1A receptor ( In a study involving exposure to a high-fat diet and chronic stress, the effects of CBD on behavior and on the expression of neuroinflammatory genes in the ventromedial prefrontal cortex and hippocampus were demonstrated (Sabbag et al., 2025)

Vasodilators such as nitrates and hemodynamic improvers such as pentoxifylline may improve circulation in the tumor decreasing anoxia

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