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aminoacyl refers to the groups H-C(N)-, alkyl-C(N)-, substituted alkyl-C(N)-, alkenyl-C(N)-, substituted alkenyl-C(N)-, alkynyl-C(N)-, substituted alkynyl-C(N)-, cycloalkyl-C(N)- substituted cycloalkyl-C(N)-, aryl-C(N)-, substituted aryl-C(N)-, heteroaryl-C(N)- substituted heteroaryl-C(N)-, heterocyclic-C(N)-, and substituted heterocyclic-C(N)- wherein alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkoxy, substituted alkoxy, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic are as defined herein

Therefore, rather than acting as a pure tumor suppressor, Notch activation in our model leads to induction of a quiescent astrocyte-like cell state which recapitulates glioma cell populations present both in primary and recurrent GBM

doi: 10.1016/j.cell.2010.02.027 139 WuJMinikesAMGaoMBianHLiYStockwellBRet al

the anti-ALPP/ALPPL2 antibodies described herein are anti-ALPP/ALPPL2 antibodies described herein

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