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Therefore, an interesting new avenue of research is that of gene-engineered antibodies called intrabodies and nanobodies, by expressing regions for antibody specificity separate from the full-length antibody

doi: 10.1021/acscentsci.9b01063 59 LohmannKRedinCTnniesHBressmanSBSuberoJIMWiegersKet al

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Furthermore, neuroprotective and disease-modifying agents, including histone deacetylase 6 (HDAC6) inhibitors and metabolic regulators like metformin, show mechanistic promise but face challenges such as poor solubility, rapid clearance, non-specific distribution, and low brain bioavailability 17,18,19,20

Methyl mercuric compounds in rat bile

Because exercise improves brain function and gut microbiome composition, its brain-protective effects in AD may be partly mediated through the microbiome