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Gene set enrichment analysis (GSEA) [48] revealed that residual tumors from mice treated with Palbociclib alone displayed a positive enrichment for gene signatures related to drug metabolic mechanisms, KD of the PTEN tumor suppressor, activation of EGFR and KRAS signaling, epithelial-mesenchymal transition, angiogenesis, and hypoxia, and a negative correlation with gene sets associated with the cell cycle, MYC targets, pyrimidine, TCA cycle and fatty acid (FA) metabolism, and DNA replication and repair (Fig