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This compensatory mechanism, however, has a narrow therapeutic window as prolonged exposure remains detrimental

Smilkstein MJ, Knapp GL, Kulig KW, et al

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Multiple infusions may be required and there may be recommended intervals between infusions

For example, IL-4 expression by microglia suppresses the release of proinflammatory cytokines such as IL-6, TNF-, or NO, contributing to the transition of microglia toward the neuroprotective phenotype (Park et al., 2005

Dominici S, Paolicchi A, Corti A, Maellaro E, Pompella A