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Forecast model & key assumptions Every forecast includes explicit documentation of: Key growth drivers and their assumed impact Restraining factors and mitigation scenarios Regulatory assumptions and policy change risk Technology adoption curve parameter Macroeconomic assumptions (GDP growth, inflation, currency) Competitive dynamics and market entry/exit expectations 6

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The current understanding based on studies from several groups is that hydroperoxide-generating enzymes called lipoxygenases (LOXs) can initiate ferroptosis by generating lipid peroxides