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Observational studies have found diminished folate status to be associated with site-specific cancers

This finding underscores the conserved role of CUL5-containing E3 ligase complexes in modulating JAK kinase stability and their impact on oncogenic signaling ( 6.2 CUL5 regulation of the NF-B/MAPK pathway CUL5 can bind to its substrate receptor protein SPSB1 to suppress NF-B activation (120)

In: White PJ, Hammond JP (eds) Significance of glutathione to plant adaptation to the environment

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