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From a different angle, it could be proposed that modest but long-term sleep deprivation (potential sleep debt) may be one of the causes of growing number of patients with obesity, diabetes mellitus and mood disorders

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The optimal injection timing for the combination is consistent from week to week, ideally the same day and approximate time each week

Briefly, 4 x lo5 spleen cells from aging (C57BW10 x DBN2)Fl mice were stimulated in culture with mitogens (concanavalin A, 0.5 p.g/well and phorbol myristate acetate, 4 ng/well) alone or with mitogens and THF-y2 or a given cytokine in various concentrations

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