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doi: 10.1016/j.cmet.2019.05.015

[156] the daily Se consumption by Saudis in the city of Riyadh was greater than for Sweden (44 g/person/day) or Greece (39 g/person/day)

The upregulation of CHAC1 leads to the depletion of GSH levels, weakening the cells antioxidant defenses and enhancing oxidative stress

Genetic and metabolic factors of individuals

Pharm Biol (2018) 56(1):7685

It is considered a marker for neuroinflammation because of its relationship to glial activation and BBB permeability ( Creatine is a critical regulator of energy homeostasis in the brain [e.g., (83)]