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The normal duration of this self-limited infection is 710 days, and it can be fatal [58]

Using a combination of protein crystallography and native MS, we have determined both the binding site and pose of two novel ligands, directly quantifying their effect on SOD1 dimerization and predicting their mode of action

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163 FOXO3 also contributes to the metabolic control of autophagy by upregulating glutamine synthetase, thereby increasing intracellular glutamine and disrupting mTORC1 lysosomal localization, which relieves the mTOR-mediated inhibition of autophagy

For instance, P115 and GRASP65 trigger apoptosis via the ERK/p53/PUMA pathway or Fas-mediated signaling, respectively, whereas Bruce and GAAP decrease apoptosis via caspase-9, Smac and p53 inhibition, and Ca 2+ signaling downregulation [93]