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In view of the highly potent nature of the constructs and the modular approach that relies on convenient synthetic methods utilizing therapeutically approved biomolecules, our method expedites the production of potent bispecific antibody constructs with tunable cell killing efficacy with significant impact on therapeutic properties

Notably, the therapeutic regimens involving CO, GSH, and their combined application both in traditional and NP formulations effectively mitigated these detrimental markers

The GGT enzyme breaks down oxidized glutathione (GSSG) to provide cysteine for de novo GSH synthesis

POLtheta processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

Both sensors showed increased oxidation during 1% and 0.1% hypoxia, which correlated with NADP oxidation, suggesting efficient equilibration between NADP and glutathione redox status via glutathione reductase in the plant cytosol

(December 2023)