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Collectively, mitochondria as the primary generators and the recipients of oxidative damage, implies a vicious cycle wherein impaired mitochondria produce increased amounts of ROS, in turn leading to a progressive accumulation of damage that culminates in the process of aging (Figure 1)

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The search was performed in multiple databases, including PubMed, Web of Science, and Embase, and was supplemented by manual searches using Google Scholar to ensure completeness

JAMA 315 , 24242434 (2016)

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