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Common symptoms of B12 deficiency include: Persistent and unexplained fatigue or weakness Lightheadedness or dizziness Pale or yellowish skin Tingling or numbness in hands and feet Muscle weakness Trouble with balance Memory problems or difficulty concentrating (brain fog) Mood changes (irritability, depression) Sore, red tongue (glossitis) If youre experiencing these symptoms, its absolutely crucial to consult your GP

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Following endocytosis, the HoloTC complex is degraded in lysosomes and free B12 is released into the cytoplasm, via CblF (Rutsch et al., 2009) and CblJ (Coelho et al., 2012)

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1% with placebo

We generally see it more in middle aged patients