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GF mice were subjected to gavage with 150 L filtered stool homogenates containing 10 7 CFU of commensal bacteria twice within a 48-h interval

Xiasangju (XSJ), a classic TCM formula composed of Prunella vulgaris L., Morus alba L., and Chrysanthemum indicum L., originates from the prescription Sang Ju Yin in the book Detailed Analysis of Epidemic Warm Diseases ( Wenbing Tiaobian ) written by the renowned Qing Dynasty physician Wu Jutong

Yet chronic HIF activation, as observed in prolonged anemia or systemic hypoxia, contributes to inflammatory signaling, tissue remodeling, and mitochondrial dysfunction, accelerating cellular senescence and organ aging [39]

10.1016/j.theriogenology.2021.11.013 13

820 In another study on HDAC resistance in solid tumors, the potential role of the activation of some kinases and downstream pathways was also reported