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Uncoupling proteins (UCP) allow proton leakage back across the inner mitochondrial membrane without generating ATP and could lower oxygen utilization for ATP production and increase oxygen consumption

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Coupled with other factors that reduce glutathione levelschronic illness, stress, aging, GMO foods and certain pharmaceuticals, your liver cannot keep up with the detoxification demands and production of glutathione

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However, it also turns out to be true that, under normal conditions, dietary intake of glutathione does not allow its direct use: since it is a tripeptide, enzymes in the gastric juices would break it down into its constituent amino acids, forcing our body to consume energy to synthesize it from scratch