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Adults For normal healthy adults, the individual maximum recommended dose of lidocaine HCl without epinephrine should not exceed 4.5 mg/kg (2 mg/lb) of body weight, and in general it is recommended that the maximum total dose does not exceed 300 mg

References: Boss A, Bishop KS, Marlow G, Barnett MPG, Ferguson LR. Evidence to support the anti-cancer effect of olive leaf extract and future directions. Nutrients. 2016;8(8):513. doi:10.3390/nu8080513

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Niture SK, Jaiswal AK (2013) Nrf2-induced anti-apoptotic Bcl-xL protein enhances cell survival and drug resistance

This risk arises from the compounded effects of bone resorption inhibition and the inherent calcium-phosphate metabolism disorders associated with CKD, as well as secondary hyperparathyroidism