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DOI: 10.1016/j.neuron.2025.05.004 De Ora, LO., Wiles, ET., Zund, M., Bauelos, MS., Haro-Ramirez, N., Suder, DS., Ujagar, N., Ayala-Angulo, J., Trinh, C., Knitter, C., Gonen, S., Nicholas, DA., Wiles, TJ

The search was conducted using the following search pattern: Acetylcysteine [Mesh] OR acetylcysteine [tiab] OR nacetylcysteine [tiab] OR n-acetyl cysteine [tiab]) OR NAC [tiab] AND ovulation [Mesh] OR total testosterone [tiab] OR progesterone [tiab] OR sexual function [tiab] OR impotence/erectile/dysfunction [tiab] OR sex hormone-binding globulin (SHBG) [tiab] AND Polycystic Ovary Syndrome [tiab] OR Ovary Syndrome [tiab] OR Polycystic Syndrome [tiab] OR Polycystic Ovary [tiab] OR Polycystic ovary disease [tiab] OR Stein-Leventhal Syndrome [tiab] OR Stein Leventhal Syndrome [tiab] OR Syndrome, Stein-Leventhal [tiab] OR Sclerocystic Ovarian Degeneration [tiab] OR Ovarian Degeneration, Sclerocystic [tiab]

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Oral cysteamine therapy has extended the time to kidney failure by approximately 7 years (to a mean of 16 years) and mitigates or prevents late complications of the disease