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Chlorogenic acid (CGA): a pharmacological review and call for further research

In this 12-week, randomised, double-blind, placebo-controlled, multicentre trial in 279 individuals with MS, the Cannabis extract (maximum daily delta-9-THC dose = 25 mg/day) produced highly significant reductions in muscle stiffness, muscle spasms, and pain relative to placebo together improved sleep quality that was evident at week-4 and maintained throughout the trial

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SAC inhibits TGF-1induced myofibroblast differentiation, downregulates AKT/NF-B signaling, and preserves thiol homeostasis

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Zhong W, Oberley LW, Oberley TD, Yan T, Domann FE, St Clair DK