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Hepatology 2022;76:174654

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The interplay between T cells and dendritic cells is promoted by pdpn-expressing fibroblastic reticular cells in conjunction with pdpn + stromal fibroblasts, facilitating the transition from innate to adaptive immunity within TLS (38, 142, 143)

Wan et al., Engineering multienzyme-mimicking covalent organic frameworks as pyroptosis inducers for boosting antitumor immunity

[29] The thiol group also has a high affinity for heavy metals, so that proteins containing cysteine, such as metallothionein, will bind metals such as mercury, lead, and cadmium tightly

These include using biodegradable backbones or enzymatically cleavable linkers, surface neutralization (for example hydroxylation, carboxylation or PEGylation) to reduce cationic surface reactivity, minimizing generation/size for dendrimers while preserving targeting, and requiring chronic-dosing safety packages that measure persistent microglial activation and behavioral outcomes before first-in-human trials