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Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration

32, 22262234, Epub 2018 Aug 2 10.1002/ptr.6159 [DOI] [PubMed] [Google Scholar] 146.Yehuda H., Soroka Y., Zlotkin-Frui M., Gilhar A., Milner Y

Synergy with GLP1 receptor agonists: CAG is being developed in combination with SemaG as a dualhormone therapy known as CagriSema

The schematic in Figure 2C captures the sequential progression of hallmark AD features, such as amyloid plaques, tau tangles, neuronal loss, gliosis, synaptic degeneration, and cognitive decline

While several antioxidant strategies, such as the use of natural products, nanomaterials, hydrogels, and microneedles have shown promise in mitigating oxidative stress and alleviating AD symptoms, there remain knowledge gaps

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