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This means that even if GSH is administered externally, there is the chance it will be degraded rapidly

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Overall, the study demonstrates the unique binding and functional profiles of the kratom alkaloids, suggesting potential utility for managing pain, but further studies are needed to follow up on these in vitro findings

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Doses exceeding ~200300 mg/day should generally be reserved for supervised therapeutic use due to potential for metabolic byproduct accumulation [15]