Principal coordinates analysis (PCoA) was performed to visualize the global metabolic profiles under both positive and negative ion modes (Supplementary Figure 1)
Minimal adverse effects observed in preclinical models
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Activation of nuclear factor-kappaB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase
Targeted analysis of polyamines by ion pairing UHPLC coupled to a triple-quadrupole mass spectrometer Targeted analysis was performed on an RRLC 1260 system (Agilent Technologies) coupled to a triple-quadrupole 6410 (Agilent Technologies) equipped with an electrospray source operating in positive mode