Hou H, Gan Y, Yin J, Jiang X
Male monkeys (aged 8-20 years) with diet induced, biopsy confirmed MASH (F1/2 fibrosis) were randomized based on baseline body weight, FAP levels and fibrosis stage, to orally administered vehicle (n=20) or AZD2389 (n=25) for 29 weeks
The targeted biologic JAK inhibitors (e.g
Periodic communications between the elephant team and veterinary team occurred in the days following an administration, with a veterinarian also conducting live observations while the elephants were at a distance within the enclosure

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Continuous use without breaks can reduce receptor sensitivity and potentially cause copper dysregulation